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  • New Platinum Drug?

    Just came across this article and wanted to share:

    http://www.medicalnewstoday.com/articles/247863.php

    Do any of the research experts have a perspective on this? Sounds promising.
    Husband Shaun diagnosed March 2010. AFP 4571, HCG 3340.
    6cm x 6cm x 8cm retroperitoneal mass + 1cm nodule in right lung.
    Stage IIIb, Intermediate Risk.
    Left I/O March 9/10: 75% EC, 20% Teratoma, 5% Yolk Sac + Seminoma.
    3xBEP + 1xEP March 15 - May 21/10: markers normal.
    Bilateral RPLND July 28/10: 9.5 x 7 x 4.5cm mass, teratoma only.
    Chylous Ascites Aug/Sep.
    November 2012 All Clear
    Continuously monitoring 0.9 x 1.7cm omental nodule (possible fat necrosis)

    www.teamshaun.wordpress.com

  • #2
    Thanks for the link, Jules! I've downloaded the article and I will read it tonight (after I make a pharmacology test that includes them knowing about the other platinums ).

    T
    Tracy
    Cancer pharmacologist, caregiver blog here

    Wife to Kel, dx 12/30/11 Stage IIIc (poor) embyronal, AFP 13700, 10x11 cm retroperitoneal mass, 1 cm^2 lung met
    Left I/O 12/31/10.
    4xBEP 1-4/11, AFP=22, 5*7 RP mass, tx failed
    1.5 x VeIP 5-6/11; tx failed, AFP/b-hCG rising
    Salvage RPLND @Indy 6/29/11, metastatic mixed germ cell tumor with yolk sac, seminoma and teratoma
    Remission! AFP steady since 9/2011; 2+ years ALL CLEAR

    Comment


    • #3
      Oh man, I would incorporate this compound into your exam. I have a soft spot for transition metal chemistry.
      "Life moves pretty fast; if you don't stop and look around once in a while, you could miss it." -Ferris Bueller
      11.22.06 -Dx the day before Thanksgiving
      12.09.06 -Rt I/O; 100% seminoma, multifocal; Stage I-A; Surveillance; Six years out! I consider myself cured.

      Comment


      • #4
        Hahaha, Fed ... you are such a chemist!

        This is the only platinum question I have, let's see if you can get it right:

        Which of the following is a good combination of drugs, as determined by following the governing guidelines of chemotherapy combinations (note: assume they have efficacy in the target cancer)?
        a. Bleomycin, paclitaxel, and vinblastine
        b. Cisplatin, oxaliplatin, and gemcitabine
        c. Mercaptopurine, 6-TG, vinblastine
        d. Bleomycin, paclitaxel, fluorouracil
        e. None of the above

        (and ugh, can I say how much I don't like squeezing a full semester of pharmacology into 4 weeks for a remediation? And I only have to deal with 1/2 of it ...)
        Tracy
        Cancer pharmacologist, caregiver blog here

        Wife to Kel, dx 12/30/11 Stage IIIc (poor) embyronal, AFP 13700, 10x11 cm retroperitoneal mass, 1 cm^2 lung met
        Left I/O 12/31/10.
        4xBEP 1-4/11, AFP=22, 5*7 RP mass, tx failed
        1.5 x VeIP 5-6/11; tx failed, AFP/b-hCG rising
        Salvage RPLND @Indy 6/29/11, metastatic mixed germ cell tumor with yolk sac, seminoma and teratoma
        Remission! AFP steady since 9/2011; 2+ years ALL CLEAR

        Comment


        • #5
          Originally posted by CancerSux View Post
          This is the only platinum question I have, let's see if you can get it right:

          Which of the following is a good combination of drugs, as determined by following the governing guidelines of chemotherapy combinations (note: assume they have efficacy in the target cancer)?
          a. Bleomycin, paclitaxel, and vinblastine
          b. Cisplatin, oxaliplatin, and gemcitabine
          c. Mercaptopurine, 6-TG, vinblastine
          d. Bleomycin, paclitaxel, fluorouracil
          e. None of the above
          Let's see...
          a. Paclitaxel stabilizes microtubules and vinblastine inhibits their formation. For all intents and purposes, these are opposite actions. Combination makes no sense.
          b. Two platinum drugs at the same time sounds redundant, so no go with this one.
          c. Mercaptopurine and 6-TG have a similar mode of action. Redundant.
          d. All of these work differently: bleo whacks DNA via a Fe dependent mechanism catalyzed by O2, paclitaxel see (a) above, and fluorouracil inhibits thymidylate synthase. Since this is the most "complementary" mix, I pick d.
          Originally posted by CancerSux View Post
          (and ugh, can I say how much I don't like squeezing a full semester of pharmacology into 4 weeks for a remediation? And I only have to deal with 1/2 of it ...)
          When I was in grad school I took a 4-week crash course in immunology. Not worthwhile to crunch a semester's worth of work into 4 weeks.
          "Life moves pretty fast; if you don't stop and look around once in a while, you could miss it." -Ferris Bueller
          11.22.06 -Dx the day before Thanksgiving
          12.09.06 -Rt I/O; 100% seminoma, multifocal; Stage I-A; Surveillance; Six years out! I consider myself cured.

          Comment


          • #6
            Originally posted by Fed View Post
            I pick d.
            Ding, ding, ding! And the prize goes to Fed (as it should)

            Originally posted by Fed View Post
            When I was in grad school I took a 4-week crash course in immunology. Not worthwhile to crunch a semester's worth of work into 4 weeks.
            These are 4 PharmD students who are re-taking a semester's worth of material in 4 weeks in order to better their understanding/grade and be allowed to advance into their clinical year. It is a new remediation policy the school is trying (if one class makes the difference between a student advancing or repeating a whole year, then they are allowed to repeat the course in the summer), but they haven't worked out the policy very well yet.

            As for the article, Jules - it is an exciting molecule! When I read the paper, what actually jumped out to me the most was the activity in NTera testicular cancer cells (that is a chorio cell line, right Fed?) with a log-greater activity than any other type of cancer cell line, and 4-fold greater activity than cisplatin. This compound is in the WAY early stages (still needs mouse efficacy data), but really promising. I'm interested (and may contact them) to see if it is active in general platinum-resistant TC cells since it works via a new mechanism. Thanks for pointing out the paper!

            T
            Tracy
            Cancer pharmacologist, caregiver blog here

            Wife to Kel, dx 12/30/11 Stage IIIc (poor) embyronal, AFP 13700, 10x11 cm retroperitoneal mass, 1 cm^2 lung met
            Left I/O 12/31/10.
            4xBEP 1-4/11, AFP=22, 5*7 RP mass, tx failed
            1.5 x VeIP 5-6/11; tx failed, AFP/b-hCG rising
            Salvage RPLND @Indy 6/29/11, metastatic mixed germ cell tumor with yolk sac, seminoma and teratoma
            Remission! AFP steady since 9/2011; 2+ years ALL CLEAR

            Comment


            • #7
              Originally posted by CancerSux View Post
              When I read the paper, what actually jumped out to me the most was the activity in NTera testicular cancer cells (that is a chorio cell line, right Fed?)
              NTERA-2 cells are actually embryonal carcinoma cells. We use them in the lab to study differentiation processes because they are about as close as we want to get to stem cell biology (plus, they have wild type p53 and boatloads of HDMX).
              Originally posted by CancerSux View Post
              I'm interested (and may contact them) to see if it is active in general platinum-resistant TC cells since it works via a new mechanism.
              That would be fascinating given the structure of the compound.
              Last edited by Fed; 07-24-12, 10:14 AM.
              "Life moves pretty fast; if you don't stop and look around once in a while, you could miss it." -Ferris Bueller
              11.22.06 -Dx the day before Thanksgiving
              12.09.06 -Rt I/O; 100% seminoma, multifocal; Stage I-A; Surveillance; Six years out! I consider myself cured.

              Comment


              • #8
                How long does it usually take from animal testing to clinical use?

                Comment


                • #9
                  Hard to make a real estimate because it depends on economics too, but 5-10 years is a safe timeline. As far as I can tell, this agent is in laboratory studies (not animals yet), but it is following the same timeline as a related platinum, picoplatin, which is in clinical trials currently.
                  Tracy
                  Cancer pharmacologist, caregiver blog here

                  Wife to Kel, dx 12/30/11 Stage IIIc (poor) embyronal, AFP 13700, 10x11 cm retroperitoneal mass, 1 cm^2 lung met
                  Left I/O 12/31/10.
                  4xBEP 1-4/11, AFP=22, 5*7 RP mass, tx failed
                  1.5 x VeIP 5-6/11; tx failed, AFP/b-hCG rising
                  Salvage RPLND @Indy 6/29/11, metastatic mixed germ cell tumor with yolk sac, seminoma and teratoma
                  Remission! AFP steady since 9/2011; 2+ years ALL CLEAR

                  Comment


                  • #10
                    Tracy and Fed, I thought we had made the rule very clear: if you are going to post extremely educational posts involving scientific material, then you need to place a warning before hand!

                    After reading this thread, I looked up from my monitor and said out loud, "my brain hurts..."

                    I'm glad you super smart people exist!
                    sigpic
                    Diagnosed 4/17/08
                    Right orchiectomy 4/18/08
                    Pure choriocarcinoma; HCG 715,000; lungs, lymphnodes, liver, and random other places
                    4X VIP chemo at IU with Dr. Einhorn 4/25/08-7/4/08
                    HCG down to 7.2 10/28/08
                    HCG back up to 198 12/29/08
                    1 X PVB 1/2/09-1/6/09
                    2 X HDC w/ stem cell rescue 2/4/09-3/14/09
                    Follow-up with Dr. Einhorn 4/22/09
                    HCG 1.2
                    3 rounds, 21 days, twice daily, VP-16 50mg 4/24/09-7/10/09

                    http://www.caringbridge.org/visit/johncovell

                    Comment


                    • #11
                      Originally posted by TC Destroyer View Post
                      Tracy and Fed, I thought we had made the rule very clear: if you are going to post extremely educational posts involving scientific material, then you need to place a warning before hand!

                      After reading this thread, I looked up from my monitor and said out loud, "my brain hurts..."

                      I'm glad you super smart people exist!
                      Yeah, my brain is spinning too after Fed's explanation... but I agree, I would have chosen D... I always choose D when my head is spinning in front of an exam.... and coincidentally that is also the mark that comes back .... glad to have smart folks(geeks/nerds/squints) aboard too ... they're the coolest.
                      Best,

                      Zsolt


                      Friendship is born at that moment when one person says to another; "What! You too? I thought I was the only one." - C.S Lewis

                      “Experience: that most brutal of teachers. But you learn, my God do you learn.” - C.S. Lewis


                      Mass found 11/20/08
                      Left I/O 11/25/08
                      Pathology: Seminoma, Stage 1
                      Surveillance: All Clear since

                      Comment


                      • #12
                        Originally posted by Aegean View Post
                        Yeah, my brain is spinning too after Fed's explanation..
                        I see your challenge, and will step up my brain spinning capabilities
                        Tracy
                        Cancer pharmacologist, caregiver blog here

                        Wife to Kel, dx 12/30/11 Stage IIIc (poor) embyronal, AFP 13700, 10x11 cm retroperitoneal mass, 1 cm^2 lung met
                        Left I/O 12/31/10.
                        4xBEP 1-4/11, AFP=22, 5*7 RP mass, tx failed
                        1.5 x VeIP 5-6/11; tx failed, AFP/b-hCG rising
                        Salvage RPLND @Indy 6/29/11, metastatic mixed germ cell tumor with yolk sac, seminoma and teratoma
                        Remission! AFP steady since 9/2011; 2+ years ALL CLEAR

                        Comment


                        • #13
                          Originally posted by CancerSux View Post
                          I see your challenge, and will step up my brain spinning capabilities
                          Hmm... may be too late... may be my new normal... huh?!? What were we talking about???
                          Best,

                          Zsolt


                          Friendship is born at that moment when one person says to another; "What! You too? I thought I was the only one." - C.S Lewis

                          “Experience: that most brutal of teachers. But you learn, my God do you learn.” - C.S. Lewis


                          Mass found 11/20/08
                          Left I/O 11/25/08
                          Pathology: Seminoma, Stage 1
                          Surveillance: All Clear since

                          Comment


                          • #14
                            Originally posted by Aegean View Post
                            What were we talking about???

                            You said Fed's post had your brain spinning, but not mine, so clearly I need to"up" the nerditude.
                            Last edited by CancerSux; 07-26-12, 12:05 PM.
                            Tracy
                            Cancer pharmacologist, caregiver blog here

                            Wife to Kel, dx 12/30/11 Stage IIIc (poor) embyronal, AFP 13700, 10x11 cm retroperitoneal mass, 1 cm^2 lung met
                            Left I/O 12/31/10.
                            4xBEP 1-4/11, AFP=22, 5*7 RP mass, tx failed
                            1.5 x VeIP 5-6/11; tx failed, AFP/b-hCG rising
                            Salvage RPLND @Indy 6/29/11, metastatic mixed germ cell tumor with yolk sac, seminoma and teratoma
                            Remission! AFP steady since 9/2011; 2+ years ALL CLEAR

                            Comment


                            • #15
                              Originally posted by CancerSux View Post

                              You said Fed's post had your brain spinning, but not mine, so clearly I need to"up" the nerditude.D
                              That's because I understand multiple choice and have a 20% chance of getting it correct just by guessing... I have no friggin' clue what he said. Oh, and you ride a motorcycle, and he doesn't... so you lose some geek/squint points... but then again geek is now the new cool.... oh I am so confused...
                              Best,

                              Zsolt


                              Friendship is born at that moment when one person says to another; "What! You too? I thought I was the only one." - C.S Lewis

                              “Experience: that most brutal of teachers. But you learn, my God do you learn.” - C.S. Lewis


                              Mass found 11/20/08
                              Left I/O 11/25/08
                              Pathology: Seminoma, Stage 1
                              Surveillance: All Clear since

                              Comment

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