Hello all!
I have recently joined the TC club (as of December 2017) and have found this site a few weeks ago. I've seen a lot of great info posted from some of you and was hoping you could help me wade through some of it with me.
I was diagnosed at an annual physical appointment at the end of November and quickly had an ultrasound and inguinal orchiectomy (12/7/17) to remove the left testicle. Pathology of the testicle reviewed pure seminoma. I had no tumor markers in the bloodwork at any time.
After CT scan, an enlarged (4cm) L iliac lymph node was discovered and a follow-up PET scan indicated cancer. I had a lymph node biopsy completed on 1/24/18, with a diagnosis of metastatic malignant germ cell tumor. The biopsy report states, however, "We cannot further sub-classify the metastatic germ cell tumor, and based on the immunohistochemical findings, cannot rule out the possibility of a non-seminomatous germ cell component"
I am scheduled for 3xBEP chemotherapy on 2/26/18, as I believe this would be the standard treatment for nearly all of TC tumor types. My concern, however, is that my doctor was not able to really communicate what about the immunohistochemical findings point toward non-seminoma, how likely is it that it is non-seminoma or what types of these TC tumors are indicated. How important is it that we know these things and if the biopsy was inconclusive, is there anything else to be done to find out?
My immunohistochemical results are below. Does anyone who has done research on these markers know what tumor types might be indicated? If I have a Stage 2b non-seminoma cancer, are any of the treatment plans different from standard 3xBEP?
OCT 3/4 - positive
Sall4 - positive
PLAP - focal positive
Pancytokeratin - focal positive
CD30 - positive, week to moderate
CD117 - negative
Thank you all for listening. For me, making these decisions is the most difficult part of this entire process.
Dave
I have recently joined the TC club (as of December 2017) and have found this site a few weeks ago. I've seen a lot of great info posted from some of you and was hoping you could help me wade through some of it with me.
I was diagnosed at an annual physical appointment at the end of November and quickly had an ultrasound and inguinal orchiectomy (12/7/17) to remove the left testicle. Pathology of the testicle reviewed pure seminoma. I had no tumor markers in the bloodwork at any time.
After CT scan, an enlarged (4cm) L iliac lymph node was discovered and a follow-up PET scan indicated cancer. I had a lymph node biopsy completed on 1/24/18, with a diagnosis of metastatic malignant germ cell tumor. The biopsy report states, however, "We cannot further sub-classify the metastatic germ cell tumor, and based on the immunohistochemical findings, cannot rule out the possibility of a non-seminomatous germ cell component"
I am scheduled for 3xBEP chemotherapy on 2/26/18, as I believe this would be the standard treatment for nearly all of TC tumor types. My concern, however, is that my doctor was not able to really communicate what about the immunohistochemical findings point toward non-seminoma, how likely is it that it is non-seminoma or what types of these TC tumors are indicated. How important is it that we know these things and if the biopsy was inconclusive, is there anything else to be done to find out?
My immunohistochemical results are below. Does anyone who has done research on these markers know what tumor types might be indicated? If I have a Stage 2b non-seminoma cancer, are any of the treatment plans different from standard 3xBEP?
OCT 3/4 - positive
Sall4 - positive
PLAP - focal positive
Pancytokeratin - focal positive
CD30 - positive, week to moderate
CD117 - negative
Thank you all for listening. For me, making these decisions is the most difficult part of this entire process.
Dave
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