just started 1xBEP

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  • markovitz
    Registered User
    • May 2017
    • 32
    #1

    just started 1xBEP

    Hello all,

    I've just started my BEP cycle.
    So, first drop in my vein, there is no turning back now

    I start with Etoposide, then cisplatin, then bleo (short in 100ml perfusion I guess).
    Around 4-5 hours.
    03/28/2017 - felt a tiny lump on my right testicle
    03/29/2017 - urology, ultra sound confirmation of tumour
    04/03/2017 - MRI abdomen/pelivis, 0.8/0.8/0.75 tumour confirmed, on upper pole of testicle, no lymph node enlarged
    04/03/2017 - blood markers normal.
    04/19/2017 - orchiectomy of the right testicle
    05/08/2017 - histopatology: 0.7/0.7/0.6 tumour, embryonal carcinoma, invasion of albugineea, LVI+ near albugineea. Spermatic cord not invaded. Associated lesions with seminoma in-situ. T2N0
    05/19/2017 - CT pelvis/abdomen/toracal , no metastasis, no adenopaties -> stage 1b
    06/11/2017 - MRI pelvis/abdomen for a restage, still no enlarged nodes, blood markers normal.
    06/13/2017 - started adjuvant 1xBEP
    Tags: None
  • markovitz
    Registered User
    • May 2017
    • 32
    #2
    All good for the first day.
    I had administrated Etoposide, Cisplatin and then Bleomicyn. Highly hidrated between and after cisplatin.
    Bleomycin was put in a 100ml perfusion and administrated in about 35min. Maybe someone could clarify this for me. Is this ok? I've read that the standard is 10-15minutes. is this really important?

    No dizziness right now, only tiredness.
    03/28/2017 - felt a tiny lump on my right testicle
    03/29/2017 - urology, ultra sound confirmation of tumour
    04/03/2017 - MRI abdomen/pelivis, 0.8/0.8/0.75 tumour confirmed, on upper pole of testicle, no lymph node enlarged
    04/03/2017 - blood markers normal.
    04/19/2017 - orchiectomy of the right testicle
    05/08/2017 - histopatology: 0.7/0.7/0.6 tumour, embryonal carcinoma, invasion of albugineea, LVI+ near albugineea. Spermatic cord not invaded. Associated lesions with seminoma in-situ. T2N0
    05/19/2017 - CT pelvis/abdomen/toracal , no metastasis, no adenopaties -> stage 1b
    06/11/2017 - MRI pelvis/abdomen for a restage, still no enlarged nodes, blood markers normal.
    06/13/2017 - started adjuvant 1xBEP

    Comment

    • JeskiM69
      Registered User
      • May 2014
      • 806
      #3
      Congrats on getting that 1st day in the books.

      I've seen it go anywhere from 15 to 45 minutes. Mine were mostly around 25 minutes or so. But one day (a new nurse) it was run fast (15 minutes) and I got pretty sick after that. You do not want to run any of these chemo drugs too fast. Better that they run slow vs fast.

      - Matt
      March 4th 2014: [AFP = 2.5; bHCG = 6; LDH = 618]
      March 13th: Left IO 100% Classic Seminoma
      6.3 x 5.1 x 3.8 cm, no invasion of anything
      LDH never fully normalized
      Stage: IS
      Watchful Waiting
      May 1st: promoted to Stage IIB with two PET active tumors in the para-aortic lymph nodes 2.5 & 2.4 cm
      May 12th: started 3xBEP
      Neupogen during Cycle 2 and 3
      July 8th: Last Bleo shot of Cycle 3 -- chemo completed !
      August 4th: Post Chemo CT/PET scan
      September 4th: Port removed
      Jan 9th 2019: 4.5 YEARS ALL CLEAR !

      Comment

      • Zicarias
        Registered User
        • May 2017
        • 43
        #4
        Glad your first day is over and went well. I wouldn't be too concerned about the timing, mine was pretty quick maybe 20 minutes but the flush before and after took a while longer. My bleo was on days 2, 9, and 16.
        26 Cleveland, OH
        3/01/17 - Found lump on right testicle
        4/21/17 - Went to ER. 4x3.7x2.5 cm tumor in right testicle
        4/22/17- Pre/op LDH 194, AFP 41, HCG 46, CT scan clear, X-ray clear
        4/27/17 - Right I/O. Non-seminoma with LVI. 70% EC, 20% Yolk Sac, 10% Teratoma
        5/16/17 - Markers normalize, CT clear. Stage 1B
        5/22/17 - Start 1xBEP

        Comment

        • Trekga
          Registered User
          • Jan 2017
          • 882
          #5
          Glad it was done. Must vary, my son's was 15 minutes for Bleo.
          Son Grant
          dx 12/21/16 at age 17
          BEP x3
          Post Chemo CT Scan on 3/28/17 still showed a few nodes over 2 cm
          2nd Post Chemo CT Scan on 4/27/17 showed all nodes still over 2cm
          Post Chemo RPLND 5/8/17: Periaortic Teratoma, Intraaorticaval Teratoma, and Paracaval Teratoma found.

          Comment

          • markovitz
            Registered User
            • May 2017
            • 32
            #6
            So far so good, with day two.

            A little bit of nausea, some hiccups, bad smell, nothing bad. I took a metoclopramide, and that's it.
            So, I had yesterday Etoposide, Serum, Cisplatin, Glucoze/Serum? , and Potasium. I try to also stay hidrated, 2l of water/day + other liquids.
            The perfusion took about 6 hours with all the breaks going to toilet, etc. Of course, they administrated me Furosemide.

            I cut my hair, and I must tell you that I was scarred as **** because I saw a brown stain on my temple. (I had longer hair before). It didn't look good to me, but I was thinking.. what are the odds... So I rushed to dermatology and they told me that i'm ok, no problem, some mild seborrheic keratosis that maybe I will remove when I'll be done with chemo.

            I've just started the third day.
            Last edited by markovitz; 06-15-17, 05:27 AM.
            03/28/2017 - felt a tiny lump on my right testicle
            03/29/2017 - urology, ultra sound confirmation of tumour
            04/03/2017 - MRI abdomen/pelivis, 0.8/0.8/0.75 tumour confirmed, on upper pole of testicle, no lymph node enlarged
            04/03/2017 - blood markers normal.
            04/19/2017 - orchiectomy of the right testicle
            05/08/2017 - histopatology: 0.7/0.7/0.6 tumour, embryonal carcinoma, invasion of albugineea, LVI+ near albugineea. Spermatic cord not invaded. Associated lesions with seminoma in-situ. T2N0
            05/19/2017 - CT pelvis/abdomen/toracal , no metastasis, no adenopaties -> stage 1b
            06/11/2017 - MRI pelvis/abdomen for a restage, still no enlarged nodes, blood markers normal.
            06/13/2017 - started adjuvant 1xBEP

            Comment

            • TC Mom
              Registered User
              • May 2017
              • 56
              #7
              My son is 16 and just completed his first long week on Tuesday - so far just a lack of appetite and nausea for him.
              He got Bleo, Etoposide, then Cisplatin, followed by 6 hours of fluids - the Bleo was infused over 15 min.
              Mom to Zachary - dx. at the age of 15 - Stage IIIC mixed germ cell
              5.10.17 - Initial diagnosis
              Baseline markers: BhCG: 43,882 AFP: 138 LDH: 328
              5.16.17 - Left Radical orchiectomy (total tumor size 7x5x4cm)
              5.31.17 - CT Scan showed mets to retroperitoneal LNs (5.7x6.4x9.4cm, 1.7x2.6x3.5cm, 3.1x4.5x6.1cm)
              PATH: Mixed germ cell (75% teratoma, 15% embryonal ca, 8% yolk sac tumor, & 2% trophoblastic tumor) Spermatic cord margin, neg. Germ cell neoplasia in situ present.

              Post-op markers: BhCG: 73,837 AFP: 38 LDH: 412

              BEP#1 6.9.17 BhCG:77,721, AFP 34
              BEP#2 7.3.17 BhCG: 210, AFP: 6
              BEP#3 7.24.17 BhCG: 19 AFP: 3
              BEP#4 8.14.17 BhCG: 4.59 AFP: 5

              8.28.17 BhCG 2.46, AFP 6
              9.7.17 BhCG 1.78, AFP 3

              RPLND 9.14.17 - path report showed 100% teratoma in nodes removed! ALL CLEAR!

              Comment

              • markovitz
                Registered User
                • May 2017
                • 32
                #8
                day three was the same, some nausea, nothing much.

                @TCMom, 6 hours of fluids.. I havn't received that much, but I guess it's ok. Anyway I tried to stay hydrated as much as I could.
                Here is the protocol for BEP, 5 day regime to whom it may concern: http://www.londoncanceralliance.nhs....tocol_v3.1.pdf
                03/28/2017 - felt a tiny lump on my right testicle
                03/29/2017 - urology, ultra sound confirmation of tumour
                04/03/2017 - MRI abdomen/pelivis, 0.8/0.8/0.75 tumour confirmed, on upper pole of testicle, no lymph node enlarged
                04/03/2017 - blood markers normal.
                04/19/2017 - orchiectomy of the right testicle
                05/08/2017 - histopatology: 0.7/0.7/0.6 tumour, embryonal carcinoma, invasion of albugineea, LVI+ near albugineea. Spermatic cord not invaded. Associated lesions with seminoma in-situ. T2N0
                05/19/2017 - CT pelvis/abdomen/toracal , no metastasis, no adenopaties -> stage 1b
                06/11/2017 - MRI pelvis/abdomen for a restage, still no enlarged nodes, blood markers normal.
                06/13/2017 - started adjuvant 1xBEP

                Comment

                • TC Mom
                  Registered User
                  • May 2017
                  • 56
                  #9
                  Originally posted by markovitz View Post

                  @TCMom, 6 hours of fluids.. I havn't received that much, but I guess it's ok. Anyway I tried to stay hydrated as much as I could.
                  [/url]
                  I think they are being extra cautious with his kidneys.

                  Sounds like you and my son are both handling it about the same. He is on day 8 of this first cycle and breezing through. He still has no appetite, and is barely eating and is nauseous, but that is it.
                  Mom to Zachary - dx. at the age of 15 - Stage IIIC mixed germ cell
                  5.10.17 - Initial diagnosis
                  Baseline markers: BhCG: 43,882 AFP: 138 LDH: 328
                  5.16.17 - Left Radical orchiectomy (total tumor size 7x5x4cm)
                  5.31.17 - CT Scan showed mets to retroperitoneal LNs (5.7x6.4x9.4cm, 1.7x2.6x3.5cm, 3.1x4.5x6.1cm)
                  PATH: Mixed germ cell (75% teratoma, 15% embryonal ca, 8% yolk sac tumor, & 2% trophoblastic tumor) Spermatic cord margin, neg. Germ cell neoplasia in situ present.

                  Post-op markers: BhCG: 73,837 AFP: 38 LDH: 412

                  BEP#1 6.9.17 BhCG:77,721, AFP 34
                  BEP#2 7.3.17 BhCG: 210, AFP: 6
                  BEP#3 7.24.17 BhCG: 19 AFP: 3
                  BEP#4 8.14.17 BhCG: 4.59 AFP: 5

                  8.28.17 BhCG 2.46, AFP 6
                  9.7.17 BhCG 1.78, AFP 3

                  RPLND 9.14.17 - path report showed 100% teratoma in nodes removed! ALL CLEAR!

                  Comment

                  • markovitz
                    Registered User
                    • May 2017
                    • 32
                    #10
                    Originally posted by TC Mom View Post

                    I think they are being extra cautious with his kidneys.

                    Sounds like you and my son are both handling it about the same. He is on day 8 of this first cycle and breezing through. He still has no appetite, and is barely eating and is nauseous, but that is it.
                    Zachary is a strong dude, I wish him well. It's perfect that they are extra cautious with his kidneys.
                    03/28/2017 - felt a tiny lump on my right testicle
                    03/29/2017 - urology, ultra sound confirmation of tumour
                    04/03/2017 - MRI abdomen/pelivis, 0.8/0.8/0.75 tumour confirmed, on upper pole of testicle, no lymph node enlarged
                    04/03/2017 - blood markers normal.
                    04/19/2017 - orchiectomy of the right testicle
                    05/08/2017 - histopatology: 0.7/0.7/0.6 tumour, embryonal carcinoma, invasion of albugineea, LVI+ near albugineea. Spermatic cord not invaded. Associated lesions with seminoma in-situ. T2N0
                    05/19/2017 - CT pelvis/abdomen/toracal , no metastasis, no adenopaties -> stage 1b
                    06/11/2017 - MRI pelvis/abdomen for a restage, still no enlarged nodes, blood markers normal.
                    06/13/2017 - started adjuvant 1xBEP

                    Comment

                    • markovitz
                      Registered User
                      • May 2017
                      • 32
                      #11
                      My fourth and fifth days were about the same. I took the pills and magnesium, a little bit of nausea, but nothing very serious. I really do have appetite, the only "problem" is that what I eat once, I can't really eat it next day, but that's ok. Also, unsalty food is just not tasty. I'm glad that now I have the days when I can eat a salty cheese or something
                      03/28/2017 - felt a tiny lump on my right testicle
                      03/29/2017 - urology, ultra sound confirmation of tumour
                      04/03/2017 - MRI abdomen/pelivis, 0.8/0.8/0.75 tumour confirmed, on upper pole of testicle, no lymph node enlarged
                      04/03/2017 - blood markers normal.
                      04/19/2017 - orchiectomy of the right testicle
                      05/08/2017 - histopatology: 0.7/0.7/0.6 tumour, embryonal carcinoma, invasion of albugineea, LVI+ near albugineea. Spermatic cord not invaded. Associated lesions with seminoma in-situ. T2N0
                      05/19/2017 - CT pelvis/abdomen/toracal , no metastasis, no adenopaties -> stage 1b
                      06/11/2017 - MRI pelvis/abdomen for a restage, still no enlarged nodes, blood markers normal.
                      06/13/2017 - started adjuvant 1xBEP

                      Comment

                      • markovitz
                        Registered User
                        • May 2017
                        • 32
                        #12
                        Today was my last bleo day. I'm netrupenic right now, count 300 if I recall correctly. The wanted to postpone bleo, but I was against so they talked and finally I've got my shot. They also gave me antibiotics for 5 days. Everything was quite easy until now. Also, today my hair gives sign that it wants to fall off.
                        03/28/2017 - felt a tiny lump on my right testicle
                        03/29/2017 - urology, ultra sound confirmation of tumour
                        04/03/2017 - MRI abdomen/pelivis, 0.8/0.8/0.75 tumour confirmed, on upper pole of testicle, no lymph node enlarged
                        04/03/2017 - blood markers normal.
                        04/19/2017 - orchiectomy of the right testicle
                        05/08/2017 - histopatology: 0.7/0.7/0.6 tumour, embryonal carcinoma, invasion of albugineea, LVI+ near albugineea. Spermatic cord not invaded. Associated lesions with seminoma in-situ. T2N0
                        05/19/2017 - CT pelvis/abdomen/toracal , no metastasis, no adenopaties -> stage 1b
                        06/11/2017 - MRI pelvis/abdomen for a restage, still no enlarged nodes, blood markers normal.
                        06/13/2017 - started adjuvant 1xBEP

                        Comment

                        • Zicarias
                          Registered User
                          • May 2017
                          • 43
                          #13
                          Glad you're on your last day! I finished 1xBEP about 3 weeks ago now and I'm essentially back to 100%. My hair did begin falling out rapidly towards the end of the last week of chemo so I shaved it to avoid looking patchy and sick. It's been three weeks since I stopped and it's only now starting to grow back and my facial hair is growing very slow. I only need to shave about twice a week. I too was neutropenic and needed IV antibiotics for a few days. It does get better, you're finished after all.
                          26 Cleveland, OH
                          3/01/17 - Found lump on right testicle
                          4/21/17 - Went to ER. 4x3.7x2.5 cm tumor in right testicle
                          4/22/17- Pre/op LDH 194, AFP 41, HCG 46, CT scan clear, X-ray clear
                          4/27/17 - Right I/O. Non-seminoma with LVI. 70% EC, 20% Yolk Sac, 10% Teratoma
                          5/16/17 - Markers normalize, CT clear. Stage 1B
                          5/22/17 - Start 1xBEP

                          Comment

                          • markovitz
                            Registered User
                            • May 2017
                            • 32
                            #14
                            And when did your neutrophiles count started to grow ?
                            03/28/2017 - felt a tiny lump on my right testicle
                            03/29/2017 - urology, ultra sound confirmation of tumour
                            04/03/2017 - MRI abdomen/pelivis, 0.8/0.8/0.75 tumour confirmed, on upper pole of testicle, no lymph node enlarged
                            04/03/2017 - blood markers normal.
                            04/19/2017 - orchiectomy of the right testicle
                            05/08/2017 - histopatology: 0.7/0.7/0.6 tumour, embryonal carcinoma, invasion of albugineea, LVI+ near albugineea. Spermatic cord not invaded. Associated lesions with seminoma in-situ. T2N0
                            05/19/2017 - CT pelvis/abdomen/toracal , no metastasis, no adenopaties -> stage 1b
                            06/11/2017 - MRI pelvis/abdomen for a restage, still no enlarged nodes, blood markers normal.
                            06/13/2017 - started adjuvant 1xBEP

                            Comment

                            • Trekga
                              Registered User
                              • Jan 2017
                              • 882
                              #15
                              Most every TC patient becomes neutropenic. After the 2nd Bleo counts should start to go back up. With BEPx3, my son lost his hair towards end of cycle 1.
                              Son Grant
                              dx 12/21/16 at age 17
                              BEP x3
                              Post Chemo CT Scan on 3/28/17 still showed a few nodes over 2 cm
                              2nd Post Chemo CT Scan on 4/27/17 showed all nodes still over 2cm
                              Post Chemo RPLND 5/8/17: Periaortic Teratoma, Intraaorticaval Teratoma, and Paracaval Teratoma found.

                              Comment

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