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4 BEP and DLCO reduction

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  • 4 BEP and DLCO reduction

    Hi everyone, my boyfriend has been diagnosed with intermediate risk tc with the components of chorio,ec and a little amount of yolk sac. He has completed 3 cycles of BEP and today he will start his 4th cycle. I am worried about lung side effects since after his PFT at thirth cycle, DLCO is now 80% compared to the initial test. We are living in France and we cannot get too much detailed information like in US. When should they stop giving B? Finally, I want to thank you all for all support and sharing information at this forum. It has been my only support during these days and really I appreciate it.

  • #2
    The predicted Normal Range for DLCO is 75% to 140%

    60% - 79% is considered a Mild Reduction
    40% - 59% is considered a Moderate Reduction
    values < 40% is considered as a Severe Reduction

    I am not sure when/if they may decide to forego the Bleo since he is still in the "Mild" range, but close to "Moderate". My guess is it would depend on who you talk to....each Dr. may have their own opinion.

    Also, how is his breathing ? Is he complaining or experiencing any obvious impacts in that area ?

    - Matt
    March 4th 2014: [AFP = 2.5; bHCG = 6; LDH = 618]
    March 13th: Left IO 100% Classic Seminoma
    6.3 x 5.1 x 3.8 cm, no invasion of anything
    LDH never fully normalized
    Stage: IS
    Watchful Waiting
    May 1st: promoted to Stage IIB with two PET active tumors in the para-aortic lymph nodes 2.5 & 2.4 cm
    May 12th: started 3xBEP
    Neupogen during Cycle 2 and 3
    July 8th: Last Bleo shot of Cycle 3 -- chemo completed !
    August 4th: Post Chemo CT/PET scan
    September 4th: Port removed
    Jan 9th 2019: 4.5 YEARS ALL CLEAR !

    Comment


    • #3
      Thanks Matt for your response. He does not have much change on his breathing. I am just afraid this Bleomycin side effect lung toxicity is not something which comes all of a sudden right? By measuring it they can detect and stop B before it happens?

      Comment


      • #4
        Bleo toxicity is actually pretty uncommon, I wouldn't stop bleo with such a small reduction. Do you know what was measured before chemo began?
        Jan, 1975: Right I/O, followed by RPLND
        Dec, 2009: Left I/O, followed by 3xBEP

        Comment


        • #5
          Shoot, I just re-read my reply above. Disregard my sentence about being close to the "Moderate" range. He is barely at the "Mild" range. I agree with Dave. I doubt this is anything to worry about yet. I know I was under 100% at my baseline and I lost 12% from chemo.

          - Matt
          March 4th 2014: [AFP = 2.5; bHCG = 6; LDH = 618]
          March 13th: Left IO 100% Classic Seminoma
          6.3 x 5.1 x 3.8 cm, no invasion of anything
          LDH never fully normalized
          Stage: IS
          Watchful Waiting
          May 1st: promoted to Stage IIB with two PET active tumors in the para-aortic lymph nodes 2.5 & 2.4 cm
          May 12th: started 3xBEP
          Neupogen during Cycle 2 and 3
          July 8th: Last Bleo shot of Cycle 3 -- chemo completed !
          August 4th: Post Chemo CT/PET scan
          September 4th: Port removed
          Jan 9th 2019: 4.5 YEARS ALL CLEAR !

          Comment

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