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Help with Interpreting my Pathology Report

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  • Help with Interpreting my Pathology Report

    Hello,

    I'm hoping we have a pathology expert that can help me understand the results I received today. Was diagnosed with a Seminoma with syncytiotrophoblastic cells (thus my small elevation in bHCG). What I have some uncertainty about is the rete testis invasion. It's says there is no invasion, but notes Pagetoid spread of GCNIS into rete testis present.

    My understanding is rete testis invasion is the one significant risk factor for recurrence in Seminoma.

    I've copied the whole path report below. If anyone has any thoughts or a similar situation I would be interested to hear your side of things. I follow up with my Urologist and Oncologist later this week and will ask them for their thoughts too.

    Template:
    TESTICLE NEOPLASM

    Specimen Laterality: Left

    Tumor focality: Unifocal

    Tumor size (greatest dimension): 3.1 cm

    Histologic type: Seminoma with syncytiotrophoblastic cells
    Seminoma: 100%
    Embryonal carcinoma: 0%
    Yolk sac tumor: 0%
    Choriocarcinoma: 0%
    Teratoma: 0%
    Other: 0%

    Rete testis invasio n: Absent for invasive seminoma. Pagetoid spread of
    GCNIS into rete testis present.

    Tumor extends beyond testis: No

    Necrosis: Absent

    Lymphovascular invasion: Absent

    Spermatic cord margin: Negative

    Extent of primary tumor: Tumor limited to testis (including rete testis
    invasion) without lymphovascular invasion and tumor 3 cm or larger in size
    (pT1b)

    Thanks,
    Patrick

  • #2
    No expert here but it pretty much says it has not spread. Based on that coupled with a CT scan if everything else is clear you should have the option for surveillance.
    Jan 2012- U/S mass in Left testicle
    Feb 2012- I/O performed to remove cancer
    Mar 1,2012- pathology pure seminoma
    Mar 7, 2012 PET SCAN stage IIa
    April 2012 Mayo clinic carbolite.
    May 2012 carbolite failed, started BEP x3
    August 7th 2012- BEP complete
    April 2013 CT/PET show relapse
    May 2013 RPLND
    Aug 2013 Relapse again Started VIeP x2
    Oct 2013 HDC AUTOLOGOUS
    Dec 2013 HDC completed CT/PETSCAN 1.1 cm x .8 cm right lower lung lobe
    Feb 2014 confirmed false positive all clear FINALLY !
    Jan 2015 1 year cancer free Pet/CT scan
    Jan 2016 2 years cancer free "Pet/CT scan
    Jan 2017 3 years cancer free "Pet/CT scan
    Jab 2018 4 years cancer free "Pet/CT scan, labs, xrays

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    • #3
      GCNIS means Germ cell neoplasia in situ. It is precursor for tumor, which means that it can eventually grow into tumor, but it is not tumor yet. As it is not tumor, it cannot metastase so you can be safe with term "Pagetoid spread of GCNIS into rete testis present" now, when everything is out. So, your tumor didn't invade rete testis.
      45yo, left I/O 07/30/2018, T1 pure seminoma, surveillance...
      Waiting...

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