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LDH test year 4

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  • LDH test year 4


    I was diagnosed with pure seminoma back in 10/2015 when I had an orchiectomy done and have been doing scans and blood work since. We have been doing observation since. I did not have any treatments outside of this. I had my blood tests and CT of Abdomen and Pelvis for my 4th year just hours ago. I got the first set of blood work back and my LDH is at 329. Around the time i was diagnosed i was at a high of 269 i believe when it went down to around 180. It has my mind going a bit. I have had some abdomen discomfort and in to my chest over the past few months. I talked with my general dr about it and he said probably nothing which i have been telling myself as well. I think it will be a life long thing for me and others I am sure, to not chalk everything up to a return of the cancer.

    I wanted to run it by this group and get peoples thoughts. Is it back?

    Last edited by bline22; 10-10-19, 12:46 PM.

  • #2
    Can't really draw any conclusions at this point yet until scans come back.

    Were your bHCG and AFP elevated at diagnosis, or normal? What are the results of those today?

    LDH is a nonspecific indicator of cell turnover. Have you done any strenuous exercise recently, had any other surgeries, pulled muscles, or other injuries? Those can also elevate it.

    If other markers and scans are normal, you probably will just have a second test in another 2-4 weeks to see if the value was an error or brief spike or not.
    6/5/15: bHCG 27,AFP 8.66, LDH 361, 5.6cm lymph node - Stage IIC
    6/16/15: Left I/O 85% EC, 10% chorio, 5% yolk sac opinion 2 (mayo) 90% EC, 10% yolk sac
    7/7/15: bHCG 56, AFP 42, LDH 322
    7/13/15: begin 4xEP, end 9/18/15
    10/1/15: bloodwork normal, ct scan shows 2 lymph nodes 1.0cm
    10/26/15: 2nd opinion on CT results - lymph nodes normal. Surveillance!
    4/6/16: 1.7cm X 1.5cm lymph node found with markers normal.
    4/20/16: RPLND @ IU - teratoma only!
    10/22/19: all clears up to this date!


    • #3
      Thanks for the reply.

      I haven't gotten the bHCG or AFP back yet. When i was diagnosed AFP (1.4) and the bHCG was at 3.2.

      Glad you mentioned the strenuous exercise as that could be it if that can raise it. I used to lift and exercise a lot prior to kids so when I go on business trips which I did earlier in the week, i generally hit it hard and am really sore as a result even yet today.

      As soon as i get the other numbers I will let you know the result.

      Thanks for calming the nerves down a bit with that.


      • #4
        If you are still sore from a workout, I would just wait a few weeks & repeat the test.
        Jan, 1975: Right I/O, followed by RPLND
        Dec, 2009: Left I/O, followed by 3xBEP


        • #5
          Thanks for the replies and reassurances.

          Scans and all look good and all other markers are good so my oncologist was not concerned. He said if it was over a 1000 he would start to be concerned.


          • #6
            Good to hear! Phew!
            Painless lump 5/18/2017
            Orchidectomy June 2017 (4.5cm, rete testis involvement)
            Chemo Summer 2017 (2x7AUC carboplatin)
            No evidence of relapse since, but plenty of anxiety about it.

            I'm also an epidemiologist, and a professor at a medical school (with NO training in oncology), oh, and gay, too.


            • #7
              Something else to think about. LDH is just measurement of cell damage. There is literally like 4 or 5 specfic LDH tests that can be run above and beyond the 1st line you had.
              Execrise, brusing, coughing to hard, liver damage. The list goes on and on as to what elevated LDH means.
              Dont fret the LDH test. High LDH could be your nee normal
              Mine has been with 10 points to 20 points of the high side normal range like clock work.
              Mine is caused by all the damage done to my body from surgeries and wearing my body out in the military. So again dont sweat it until you have other things combined with high LDH to show TC concern
              Jan 2012- U/S mass in Left testicle
              Feb 2012- I/O performed to remove cancer
              Mar 1,2012- pathology pure seminoma
              Mar 7, 2012 PET SCAN stage IIa
              April 2012 Mayo clinic carbolite.
              May 2012 carbolite failed, started BEP x3
              August 7th 2012- BEP complete
              April 2013 CT/PET show relapse
              May 2013 RPLND
              Aug 2013 Relapse again Started VIeP x2
              Oct 2013 HDC AUTOLOGOUS
              Dec 2013 HDC completed CT/PETSCAN 1.1 cm x .8 cm right lower lung lobe
              Feb 2014 confirmed false positive all clear FINALLY !
              Jan 2015 1 year cancer free Pet/CT scan
              Jan 2016 2 years cancer free "Pet/CT scan
              Jan 2017 3 years cancer free "Pet/CT scan
              Jab 2018 4 years cancer free "Pet/CT scan, labs, xrays