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How does choriocarcinoma typically present?

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  • How does choriocarcinoma typically present?

    Was dx'd with primary mediastinal seminoma on 11/2015. Tumor was 10 x 15 x 20cm (AFP normal, HCG 1,500). Received 3 x BEP, 1 EP. Clean scans and blood work for the past 4 years.

    Last week, felt a pain on the side of my neck (no other symptoms). Two days later, a soft lump appeared (~2-3cm). A FNA biopsy was done today. Preliminary feedback was that there were a few atypical cells that, apparently, did not look like a head and neck cancer or a lymphoma, but may be consistent with a germ cell. Interestingly, the pathologist mentioned that it might be choriocarcinoma. I am awaiting AFP and HCG results, too. The formal pathology report will be out tomorrow after the slides are stained, etc.

    Any insight from anyone on how choriocarcinoma typically presents?


  • #2
    Hi MattU,

    I remembered someone had same problem. But I could not really remember the whole story.

    I think you perhaps need waiting of your pathology report and then make next action. When it is late recurrence of seminoma, I think there are many possibilities to choose. If it is another type TC, you have to really review the slides four years ago. Then seeking an TC expert.

    Best wishes.

    Ranís mom
    Son Ran, 24 years old, 25th May 2018 diagnosed NSGCT. 28th May 2018 right orchiectomy. Pathology:50% EC, 30% Teratoma ,20% Yolk sac. CTs: 1 retroperitoneal lymph node 0.7mm Tumor markers: AFP 497, bhcg 19, LDH normal Normalized after R/O. Stage 1, surveillance 17th September 2018, Bhcg elevated up to 5.6 AFP and LDH normal, CT stable. 4th November bhcg up to 28, AFP and LDH normal. BEPx3 started and 2nd January 2019 BEP finished with Tumor markers normalized. 13th February 2019 CT scan showed 1 retroperitoneal lymph node enlarged up to 1.1 cm with normal tumor markers. RPLND : 03/14 2019@IU Dr.Cary Pathology report: one lymph node from 57 is Teratoma .Back to surveillance 05/02/19 Blood work all normal

    08/23/2019 normal
    12/04/2019 normal.
    04/01/2020 normal.


    • #3
      Please keep us informed.