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Upgraded to 2xTC and starting TRT

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  • Upgraded to 2xTC and starting TRT

    Hi everyone,

    First, a quick summary of my case.
    I lost my right nut in July 2011, stage 1a 100% seminoma. Been on surveillance since then without any reocurrence.
    Fast forward to 27 Dec 2019, in one of my follow-up consults, my doc noticed something on 'lefty', ultrasound it and boom, 3.4cm mass in there...
    Had my orchy one month later (I live abroad, so I had to care of some issues before having surgery in my own country) and right now still waiting for pathology. CT scan shows a slightly enlarged abdominal lymph node (around 12mm), so still waiting on the next steps.

    I'm about to start TRT. Chose long term injections (Nebido) due to the "inject and forget" approach. My total testosterone level before orchy was around 600 ng/dl (was 540 in 2016) and I felt quite good. Now I have the astonishing value of 10 ng/dl... However, besides no libido and no erections since the orchy, I actually feel okay so far...

    My question is related to all 2 timers on Nebido here in the forum.
    How do you feel compared to when you were single nutted? Energy levels, libido, bodyweight, etc...
    And how do you control the testosterone level? Blood tests just after injection and before next injection?
    I am quite athletic, running 4-5x per week and going to the gym also 3-4x, so I was wondering the energy levels while on Nebido...

    Thanks for your input and good luck to everyone...
    July 2011: Right I/O. Pure seminoma stage 1B. Surveillance.
    January 2020: Left I/O. Pure seminoma. Borderline lymph node - awaiting repeat CT scan...

  • #2
    I am not a two timer but was only born with one, so a similar boat via different roads.

    I believe Nebido is the same as Aveed here in the states. I have been on Aveed for about 3 years now.

    I feel good, similar energy levels and libido. Occasional ED issues however not too sure what to attribute it to as on Aveed my levels are right where they were pre I/O. Old age? Other hormones? Still exploring this with docs. For now a small dose of generic cialis works perfect.

    With Aveed, it isn't really adjusted. You take it every 10 weeks and that's really it. Here in the states, the FDA has only approved a single dose amount at that exact interval. No titration or dose/schedule adjustments. But for me, it has kept me right where I was pre I/O and it is excellent to not have to worry about gels or self injections or the T level roller coaster.

    You should start a different TRT first to get your levels to the normal range before starting Aveed however. Aveed is a slow release, long half life medicine. If you start from practically zero T it will take a LONG time to get your levels up, probably 10+ weeks or two months.
    6/5/15: bHCG 27,AFP 8.66, LDH 361, 5.6cm lymph node - Stage IIC
    6/16/15: Left I/O 85% EC, 10% chorio, 5% yolk sac opinion 2 (mayo) 90% EC, 10% yolk sac
    7/7/15: bHCG 56, AFP 42, LDH 322
    7/13/15: begin 4xEP, end 9/18/15
    10/1/15: bloodwork normal, ct scan shows 2 lymph nodes 1.0cm
    10/26/15: 2nd opinion on CT results - lymph nodes normal. Surveillance!
    4/6/16: 1.7cm X 1.5cm lymph node found with markers normal.
    4/20/16: RPLND @ IU - teratoma only!
    10/22/19: all clears up to this date!


    • #3
      I'm not on aveed, but on generic testosterone cypionate every 3 weeks. My doc only orders testing every so often ( no more than twice a year)& wants the tests done on day 10-11 of the 21 day cycle. The numbers are usually on the low end of normal. For the most part I'm satisfied with it, even though I think it could be better. Hope that helps.
      Jan, 1975: Right I/O, followed by RPLND
      Dec, 2009: Left I/O, followed by 3xBEP


      • #4
        Hi again.
        Thank you for your replies .

        I had my 2nd Nebido injection 10 days ago (a bit less than 8 weeks after the 1st injection).
        My TT level one day before this 2nd injection was 380 ng/dL (approx 13.2 nmol/L).
        The TT level today is 1350 ng/dL (approx 46.8 nmol/L), which is surprisingly high.

        I will now go through the normal 12-week injection cycles, monitoring the levels before and after injections.

        Despite the levels being quite good, since before the 1st injection I had basically no testosterone (10 ng/dL), I am still putting a little weight, approx 5 kg, especially in the mid-section.
        I'm taking care of what I eat and exercising regularly (always kept walking, started light weight training 1 month after I/O and started running 2 months after I/O).

        I know that TRT (especially long-term injections) take time to normalise all aspects (libido issues first and body composition later).
        But just wanted to check here in the forum if anyone went through similar issues.

        July 2011: Right I/O. Pure seminoma stage 1B. Surveillance.
        January 2020: Left I/O. Pure seminoma. Borderline lymph node - awaiting repeat CT scan...


        • #5
          Adding to this rather than starting a new topic so please bear with me if I have this wrong.

          I'm a new double warrior having had both testicles removed 11 days ago. Before this I understand I was relatively inefficient at producing Testosterone as a result of undescended testes as a child (the way it was put to me was my brain was 'screaming' at my testes to produce). I don't have blood levels to hand - I need to discuss obtaining this from my GP/Hospital

          I had a 250mg Sustenon injection in my right arm the day after my operation. This has led to pain at the injection site which is only subsiding now and a period of a couple of days last week where I was very tired and may have had hot flushes a few evenings (or it could have been the heating turned up to 75deg F for the benefit of my Mum)

          I have a consultation with the GP tomorrow to discuss the way forward. The options the hospital have given are

          Sustenon 2-3 weekly
          Nebido 10-14 weekly
          Testosterone Gels
          Buccal administration (pouch against the gums? Not overly keen on that...)

          I'm trying to read up as much as possible before the consultation to determine my preference all things being equal. I think I would prefer to go down the frequent and stable path, or at least I was thinking that before my experience with the Sustenon first time round, but I would be interested in views. Is the gel even an option given this is now my primary source of Testosterone?

          The cost is not so much of an issue as I am obtaining this via the UK National Health Service (they might have objections but the options have already been put forward so I expect this to be standard)

          One final note - so far my libido is still, ahem, hanging in there (considering I'm 52 and recovering from an operation anyway)


          Update - I have decided to go for the Sustenon until I know how I am getting on with it. One additional issue is that I live with my Mother who is on Warfarin for Thrombosis so the idea of she being exposed to the gel directly or indirectly has put me off that.
          Last edited by Edamole UK; 02-11-21, 07:04 PM. Reason: Updated with decision


          • #6
            So, three courses in (fourth this Thursday) and I'm still with the Sustanon. It's literally a pain in the backside for the first 5 days or so (particularly, I find, if and when I do a lot of movement/exercise) but I'm settling into the routine now.

            I've also had a peak/trough testosterone test around my last Sustanon injection - Friday 6nmol/l, Monday >52nmol/l. So I understand the 6 is too low and the >52 also low for just having had the jab (although how much higher it is remains to be seen).


            • #7
              Odd that it should hurt that long.The few times I've had pain it was only 1-2 days.How many days after the injection was the "high" test taken? I was told the cypionate takes about 3 days to reach it's peak
              Jan, 1975: Right I/O, followed by RPLND
              Dec, 2009: Left I/O, followed by 3xBEP


              • #8
                Injection was 5pm on the Friday, test was 11am on the Monday do 2.5 days really. The interesting thing is it says >52nmol/l so it could be more. I think I might ask for another pair of tests in a couple of weeks' time for comparison.

                Pain is definitely more than 2 days - carries over to the following week. As I recall I thought it had settled down last time but then I had a day where I moved around a lot and the pain came back - almost as if the blood flow had kicked the reaction off again.I've got my next dose on Thursday so I'll see how that goes...