Hello all,
I have noticed that many guys here have presented recently with pure EC, which is surprising since the low prevalence of this kind of tumor.
I have gathered some data on pure EC for those guys here who have this form of TC. Sorry for the long post, guys ! When I came to this forum, I had much questions and I found answers for some during these last months. I share you today the results of these long searches.
TC is treated according to stage, but clinicians must acknowledge that the orchiectomy specimen contains precious informations. Pure EC acts quite differently than other NSGCT.
For guys who have (or had !) pure EC, you can post here your story or other things about pure EC if you want, so we can discuss of this without invading personal post. I’m sure future forum members will be happy to have this.
So, here it is :
Pure EC :
Clinical data :
I try to found the most pertinent clinical data on pure EC. Data is not exhaustive.
Princess Margaret Hospital in Toronto (Canada)
https://www.ncbi.nlm.nih.gov/pubmed/21190791
Case report (Netherlands)
https://www.ncbi.nlm.nih.gov/pubmed/18307023
MSK in New York (USA)
Testicular Intergroup Study
http://www.ncbi.nlm.nih.gov/pubmed/1309382
ASCO meeting
Princess Margaret Hospital in Toronto (Canada)
http://meeting.ascopubs.org/cgi/cont...33/7_suppl/377
Finally, sorry for some English mistakes (still trying to improve !).
Jean-Philippe
I have noticed that many guys here have presented recently with pure EC, which is surprising since the low prevalence of this kind of tumor.
I have gathered some data on pure EC for those guys here who have this form of TC. Sorry for the long post, guys ! When I came to this forum, I had much questions and I found answers for some during these last months. I share you today the results of these long searches.
TC is treated according to stage, but clinicians must acknowledge that the orchiectomy specimen contains precious informations. Pure EC acts quite differently than other NSGCT.
For guys who have (or had !) pure EC, you can post here your story or other things about pure EC if you want, so we can discuss of this without invading personal post. I’m sure future forum members will be happy to have this.
So, here it is :
Pure EC :
- About 2 – 4 % of all TC
- Usually do not produce AFP
- Modest elevation in serum bHCG
- High propensity to invade (LVI is common)
- Agressive germ cell tumor
- Most undifferentiated cell : pluripotent, may transform in other specialized cells (choriocarcinoma, yolk sac or teratoma)
Clinical data :
I try to found the most pertinent clinical data on pure EC. Data is not exhaustive.
Princess Margaret Hospital in Toronto (Canada)
https://www.ncbi.nlm.nih.gov/pubmed/21190791
- Stage I NSGCT
- All treated with surveillance (as recommended by Canadian guidelines)
- 56 patients with pure EC (15 % of total cohort)
- 23 patients with LVI and pure EC : 12 relapsed (relapse rate : 52 %)
- 33 patients without LVI and pure EC : 15 relapsed (relapse rate : 45 %)
- Relapses mostly retroperitoneal and in the good prognosis group (personal communication with lead author) for pure EC
- Other results presented are pooled, so not specific to pure EC.
Case report (Netherlands)
https://www.ncbi.nlm.nih.gov/pubmed/18307023
- Case report of a 19 YO with stage 1B pure EC
- Treated with surveillance after orchiectomy
- Relapsed more than 1 year after orchiectomy with retroperitoneal mature teratoma (1.8 x 1.4 cm)
- RPLND performed
- Illustrates that pure EC may transform to teratoma WITHOUT chemotherapy (first case report of this)
MSK in New York (USA)
- 45 patients with pure EC
- 29 patients with LVI
- 26 patients were clinical stage I ; 17 stage IIA ; 2 stage IIB
- All initially managed by RPLND
- 76 % of patients have retroperitoneal disease at diagnosis: 76 % with LVI ; 75 % without LVI
- 7 patients pN0 (no metastasis)
- 10 patients pN1
- 24 patients pN2/N3
- Retroperitoneal pathology
- Pure EC in 76 % patients
- Pure yolk sac in 1 patient
- Mixed NSGCT in 21 % patients with 3/7 patients with teratomatous elements
- pN0 : 0 patient relapsed after RPLND
- pN1 : 1/9 patient relapsed after RPLND
- pN2/N3 : 3/24 patients relapsed after RPLND
Testicular Intergroup Study
http://www.ncbi.nlm.nih.gov/pubmed/1309382
- 69 % of patients with clinical stage I pure EC have retroperitoneal pathologic disease at diagnosis
ASCO meeting
Princess Margaret Hospital in Toronto (Canada)
http://meeting.ascopubs.org/cgi/cont...33/7_suppl/377
- About 90 % of patients achieve complete response with chemotherapy if pure EC in the orchiectomy specimen
- Similar to data from MSKCC (about 7 % teratoma if pure EC in the orchiectomy specimen)
Finally, sorry for some English mistakes (still trying to improve !).
Jean-Philippe
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