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Weird drop in AFP

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  • Weird drop in AFP

    I’m late recurrence, original was ~8 years ago. Relapse this year.
    My afp rose to 33xx I had 4 rounds of EP (discussed before). I a week after the last round afp had dropped to 24xx.

    I went to MD Anderson to look into/ schedule high dose chemo with stem cell transplant. They did a workup (for insurance pre approval). My blood work was posted just now.
    Afp 409. I’ve had no chemo for about 1.5 months.

    Should I be encouraged by this huge drop?

  • #2
    Well, its definitely not a bad thing! Numbers dropping is good, meaning disease volume probably has reduced and it isn't totally chemo resistant at least. It definitely doesn't put you out of the woods though.
    6/5/15: bHCG 27,AFP 8.66, LDH 361, 5.6cm lymph node - Stage IIC
    6/16/15: Left I/O 85% EC, 10% chorio, 5% yolk sac opinion 2 (mayo) 90% EC, 10% yolk sac
    7/7/15: bHCG 56, AFP 42, LDH 322
    7/13/15: begin 4xEP, end 9/18/15
    10/1/15: bloodwork normal, ct scan shows 2 lymph nodes 1.0cm
    10/26/15: 2nd opinion on CT results - lymph nodes normal. Surveillance!
    4/6/16: 1.7cm X 1.5cm lymph node found with markers normal.
    4/20/16: RPLND @ IU - teratoma only!
    4/15/19: all clears up to this date!


    • #3
      hi Pswuba,
      This is VERY interesting and certainly something positive.

      Could it be a late reaction to the chemo? Probably it is still working in your body, meaning your cancer is pretty chemo sensitive which is the best news ahead of the high dose chemo. I hope you can arrange that.

      Are you taking any supplements btw ?

      All the best and please keep us posted on your discussion with the onco team. Sending positive vibes.



      • #4
        Chemo's effects such as apoptosis last weeks after it is completed. So, this is not very unusual.
        Jan '11 - Stage IIIc, Mets in lungs and liver, abdo 7*7, pulmonary embolism
        Right I/O AFP 13,000, bHCG 110, Scrotal Hematoma, IVC Filter
        4*BEP AFP 20 end of 4*BEP
        May '11 - RPLND @ Indiana U - inferior vena cava dissected, necrosis, AFP<5
        Surveillance (blood & X rays) and all clear for 24 months
        April '13 - AFP 26 , went up to 46 in a week, Negative CT Scan, Ultrasound and head MRI
        4xTIP - almost normal AFP, but started rising again
        2 x HDC with Autologous Stem Cell Transplant - AFP almost normal but started rising again
        Lost kidneys, damaged liver, chirhosis, ascites 2 liters per day, dialysis 3 times per week, disabled
        2 Lung Wedge Resections -