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Does LVI mean likely spread?

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  • Does LVI mean likely spread?

    My pathology report says that there was lymphatic and vascular invasion. The cancer type was seminoma. I'm getting scans done on May 29th, but does anyone have any information showing the likelihood that the cancer has spread based on the type of cancer being seminoma in the fact of lymphatic and vascular invasion? If relevant, the largest nodule was 2.5 x 2.3 x 2.1 centimeters, in the other two nodules or 0.9 and 1.5 centimeters. Thanks for reading and any insight that you can provide.

  • #2
    LVI means that it is more likely to have spread than if it wasn't present. Whether it means that it more likely than not to have have spread, I'm not sure. However, seminoma moves more slowly than non-seminona.

    My urologist explained things to me in a way that that i found reassuring. He said that if the cancer was found to have metastasized, the outcome would still be the same - basically a full cure - but the journey would be different.

    May 29th seems a while off. Can you get that moved up?

    Where in the world are you?



    Embryonal Carcinoma; Seminoma. Marker negative.
    August 2001: Right I/O .
    August - December 2001: Surveillance .
    December 2001: Relapse - Stage III. Mets in lymph nodes and lung.
    December 2001 - March 2002: 3xBEP .
    Complications: Neutropaenic sepsis during cycles 1 & 3. I/V antibiotics and isolation.

    March 2012 - Ten years since finishing chemo.

    Survivorship Blog is here


    • #3
      I have LVI as well. If I am reading this study correctly, LVI increases recurrence chances by 2%-3% depending on what course you take (Surveillance, or Carbo in this study.)

      Look at table 1 here:

      There are lots of studies out there... I don't know the source of this info, or if it is the most current.

      6/4/18 BHCG 452, AFP 1
      6/13/18 CT Scan, no involvement beyond left testicle
      6/18/18 Radical Left inguinal orchiectomy, Pathology pure seminoma, rete testis obliterated
      6/29/18 BHCG 7, AFP 1.5 (calc 1.8 half-life)
      7/12/18 BHCG<1, AFP 1.5, LDH 220, Diagnosed as Stage 1b, T3N0
      7/25/18 Adjuvant Chemotherapy, 780mg Carboplatin
      8/27/18 Chest CT Scan clear
      9/7/18 BHCG<2, AFP 2.0, LDH 182 (Different lab w/diff ranges than initial tests)
      9/26/18 MRI to review liver cysts for possible metastasis, all clear. No lymphadenopathy
      11/23/18 CT Scan, "No evidence of residual or recurrent disease, no lymphadenopathy or evidence of metastasis"
      11/27/18 BHCG<2, AFP 2.0, LDH 173
      5/24/18 BHCG<2, AFP 2.0, LDH 161
      6/17/19 12 months - all clear. "Cancer-Free"


      • #4
        Thanks for the responses. I'm in Missouri, in the United States. My oncologist scheduled the scans for 6 weeks out because she said that sometimes the surgery will cause tissue to appear on the scan because of the surgery and not because of cancer. My urologist thought that, if my oncologist were truly concerned about the cancer having spread and causing problems quickly, she would have scheduled me sooner.

        That's interesting information about relapse. I wonder if there are similar studies on the likelihood that seminoma cancer has spread based on lymphatic and vascular invasion alone. I've searched and haven't been able to find anything. And perhaps there are no studies because, in any event, a patient would need to have scans done anyway.


        • #5
          While the chance of spread generally is considered increased wit LVI, I cannot recall any exact percentage of increase. While trying to not worry right now is difficult, just keep in mind that your cure rate is very, very high, even if it has spread. The only thing unknown is what path you might take to get to the cure.
          Jan, 1975: Right I/O, followed by RPLND
          Dec, 2009: Left I/O, followed by 3xBEP